Citotoxyc and apoptotic activity of extracts from leaves and juice of passiflora edulis

Liver cancer is the fifth most frequent neoplasm in men and the ninth in women, with 782,000 new cases of cancer diagnosed in 2012, is the second cause of death associated with cancer in the world, with 746,000 deaths in 2012.1 Hepatocellular carcinoma (HCC) is the most common type of liver cancer. It is produced by the transformation of hepatocytes and is common in patients with cirrhosis, considered the pre-neoplastic state.2 Among the main risk factors are infection with hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol intake, dietary exposure to Aflatoxin B1 (AFB1) and tobacco, among others3 Likewise, in recent years it has been shown that diabetes mellitus and other factors associated with the metabolic syndrome such as obesity or dyslipidemias, favor the increase in the incidence and mortality rates of HCC.4 del CHC.